SAASCR Honors GIOSTAR Chairman Dr. Anand & 9 Indian American Scientists for Their Outstanding Cancer Research
Srivastava has been associated with leading universities and research institutes in the U.S. He held faculty positions at leading universities and research institutes such as University of California San Diego Medical School, University of California Irvine Medical College, Salk Research Institute in San Diego, Burnham Institute for Medical Research in San Diego, University of California, Los Angeles. He presently holds positions in scientific advisory boards of several institutions like Heamgen Inc., Celebration Inc. Srivastava’s expertise and scientific achievements were recognized by many scientific awards/ fellowships.
Presently, he is the chairman of the Global Institute of Stem Cell therapy and Research, USA. Under his leadership, GIOSTAR is opening stem cell therapy and research centers globally that are using stem cell therapy to treat ailments like cancer and other degenerative diseases.
GIOSTAR Announces FDA Approval Under Compassionate Use for a COVID-19 with Stem Cells
GIOSTAR Received FDA Approval Under Expanded Access For Use of Stem Cells to Treat COVID-19 Patients
Under expanded access, also known as compassionate use, the U.S. Food and Drug Administration (FDA) has approved GIOSTAR the emergency use of stem cell therapy to treat acute inflammation of the lungs in hospitalized patients diagnosed with COVID-19. Expanded access allows patients to receive stem cell therapy on a case-by-case basis outside of a conventional clinical trial as deemed appropriate by the treating physician, the GIOSTAR medical director and the FDA. Each patient will be assessed to determine if stem cell therapy is appropriate and a separate Investigational New Drug (IND) application will be filed for the FDA’s approval every single time. Patients will be evaluated after the infusion of the stem cells and the outcome of the treatment will be submitted to the FDA regularly.
COVID-19 infection causes an acute flow of inflammatory cytokines like IL-6, GCSF, IP10, MCP-1, MIP1A, and TNF-α in the lungs, which cause and promote formation of microthrombi. These microthrombi can block normal flow of blood in any part of the body leading to pathogenesis in the afflicted organ. This could be a very probable reason as COVID-19 has been shown to affect any part of the body like brain, heart, kidneys, intestines and of course the lungs.
Groundbreaking research provides a promising potential alternative to devastating pandemic
Global Institute of Stem Cell Therapy and Research (GIOSTAR), the worldwide leader in stem cell research, is pleased to announce that they have received an approval for COVID-19 clinical trial, led by their Medical Director Dr. Prabhat Soni. GIOSTAR will conduct the trials using stem cells to treat COVID-19 patients, under the approval of the United States Food and Drug Administration (FDA) “expanded access for compassionate use” program. The Institute is exploring a promising alternative approach to the devastating disorder, which leverages the anti-inflammatory properties of mesenchymal stem cells (MSCs). According to Dr. Soni, the investigation is based upon two decades of stem cell research by GIOSTAR Co-Founder, Chairman and Chief Scientific Officer Dr. Anand Srivastava.
The COVID-19 pandemic has resulted in unprecedented disruption, with more than 3 million cases and 200,000 deaths reported worldwide as of May 1, 2020 – a figure that is projected to grow exponentially in the weeks ahead. Caused by a pathogenic virus known as SARS-CoV-2, the infection induces a broad range of responses in humans: some patients are asymptomatic, others develop mild flu-like discomfort, and still others suffer from severe pneumonia. Physicians have resorted to numerous traditional and unconventional therapies to combat the effects of COVID-19. These therapies – which include antibiotics and plasma therapy – have proven largely ineffective in managing the spread of the pandemic.
A Novel Approach to Inflammation
Given these challenges, there has unsurprisingly been a surge in clinical trials for use of MSC’s to combat COVID-19. Cedars-Sinai Medical Center recently cited studies that “support the notion that cell therapy can attenuate inflammation, which may be attractive in COVID-19.” One study by an international coalition of researchers from China, United States, India, France, and other countries appeared in Aging and Disease, showing full recovery of seven COVID-19 patients 2 weeks after receiving intravenous (IV) administration of allogeneic (sourced externally from donors) MSCs.
COVID-19 is induced by a release of signaling molecules known as cytokines – small protein molecules released by immune cells to orchestrate the “attack-and-destroy” mode of the host’s immune system response to pathogens. Cytokines are either proinflammatory (“bad”) or anti-inflammatory (“good”), meaning that they either increase or decrease levels of inflammation in the body. In the case of COVID-19, an uncontrolled immune response leads to a “cytokine storm,” dramatically raising levels of IL-6, IL-8, and TNF-alpha and other proinflammatory proteins. The immune system then goes into “overdrive” mode, thereby causing potentially fatal damage to the patient’s own tissues and organs.
Drs. Srivastava and Soni sought to leverage and apply extensive research demonstrating the effectiveness of MSCs in combating the respiratory symptoms and cytokine storms associated with COVID-19. “The cells have specific characteristics that, when infused in the bloodstream,” Dr. Srivastava explained in an educational video, “neutralize the proinflammatory cytokines, down-regulate the inflammatory gene actions (through ‘immunomodulation’), and send messages to regenerate damaged lung tissues.”
Seeing great potential in this therapeutic approach, the FDA approved MSC-based treatment for use in the most severe cases of COVID-19, under their “expanded access for compassionate use” program. The first patients will be treated in New York City. The city has been among the most severely impacted regions of the country, with more than 170,000 confirmed cases of COVID-19 and 13,000 deaths as of May 1, 2020.
“GIOSTAR appreciates the FDA for their timely action in approving the protocol,” noted Dr. Soni. “We’re looking forward to sharing the findings from our studies with the world, which may help save many lives in the future.”
GIOSTAR is the pioneer and established leader in the field of stem cell research. Under the leadership of Co-Founders Dr. Anand Srivastava and Deven Patel, the San Diego-based Institute has a tradition of groundbreaking research in stem cell science spanning more than two decades.
CHANDIGARH, India, Feb. 5, 2020 /PRNewswire/ — GlobalInstitute of Stem Cell Therapy and Research (GIOSTAR), a leading provider of regenerative medicine, is proud to announce the inauguration of a new stem cell / cancer research and therapy center in Chandigarh, India. This facility represents the latest milestone in global expansion efforts spearheaded by GIOSTAR in India, Mexico, the United States, and numerous other countries.
GIOSTAR Chandigarh occupies 4 stories and 12,000 square feet, with a sleek, modern design that “reflects the cutting edge, elite science that GIOSTAR has been delivering for over two decades,” according to GIOSTAR Co-Founder and CEO Deven Patel. Following the recent opening of a center in New Delhi, it is the most recent in a series of hospitals being launched throughout the country. Future plans for expansion include Kolkata and Bangalore.
Chandigarh is noteworthy for having been the first planned city in India, designed by famed Swiss architect Le Corbusier. Located in Northern India, it is one of the country’s wealthiest cities, ranking the highest for Human Development Index (HDI) (a measurement of standard of living, literacy rates, and life expectancy). In addition to its verdant gardens and abundant shopping and dining offerings, Chandigarh is home to several prestigious research institutions such as Panjab University and Baba Farid Medical University.
Several key luminaries in the field of medical research, including Drs. S. S. Gill, Sanjeev Puri, Seemha Rai, and Amandeep Singh participated in the inauguration, delivering remarks about the state of regenerative medicine in India. “GIOSTAR is proud of our tradition of excellence in research,” noted GIOSTAR Co-Founder and Chairman Dr. Anand Srivastava, “and we are privileged to welcome such influential leaders in the field on this auspicious occasion.”
Continued Collaboration, Sustained Impact GIOSTAR has long played a central role in the evolution of regenerative medicine within India. This began with the 2011 launch of the world’s first dedicated stem cell therapy hospital in Gujarat, resulting from a landmark partnership with Prime Minister of India Shri Narendra Modi. GIOSTAR is also collaborating with a few state governments of India. “These partnerships have been very beneficial,” noted Patel, “as they enable GIOSTAR to deliver regenerative therapies to millions of people suffering from degenerative disorders and cancer.”
Additional highlights of GIOSTAR’s worldwide efforts include:
Launch of a stem cell therapy center in Cancun Rivera, Mexico, regarded as one of the world’s premier tourist destinations
Collaboration with large pharmaceutical company in China to launch clinical trials for cerebral palsy for children
Conditional approval for Type 2 Diabetes clinical trial in Bahamas, where nearly 15% of the population suffers from the disease
In-depth discussions between delegations of Ahmedabad, India and Kobe, Japan, to foster additional investment opportunities between the two “sister cities”
Process of FDA approval for clinical trials for Type 2 Diabetes and other disorders in the United States
“2020 will be a very bright year, with unlimited potential for the field of regenerative medicine,” noted Patel. “There’s a great deal of work yet to be done, however, and GIOSTAR will continue leading the charge – in Chandigarh, and around the world.”
GIOSTAR is the pioneer and established leader in the field of regenerative medicine for sports injuries, joint arthritis afflictions, and additional degenerative conditions. The Institute’s advanced techniques and protocols have been extensively researched and developed by Dr. Anand Srivastava and GIOSTAR’s leading scientists for more than 20 years.
PLAYA DEL CARMEN, Mexico, Jan. 14, 2020 /PRNewswire/ — Global Institute of Stem Cell Therapy and Research (GIOSTAR), the pioneer in stem cell-based technologies, is proud to announce the launch of a new stem cell therapy center in the Cancun Riviera, Mexico. With this announcement, GIOSTAR further bolsters its leadership in the global medical tourism market, which is projected to grow at a compound annual growth rate (CAGR) of 16.1% for the next 5 years. The Cancun Riviera center highlights GIOSTAR’s continued expansion of its presence in Mexico, which also includes facilities in Los Algodones and Guadalajara.
Stem cells are unspecialized unique body cells that may help patients better manage symptoms of multiple sclerosis, arthritis, and other degenerative diseases. In addition to its clinics such as GIOSTAR Cancun Riviera, the GIOSTAR management team collaborates closely with leading government agencies to create stem cell therapy and research programs in Japan, China, Costa Rica, and Thailand. “This center is a testament to the commitment from the thousands of patients GIOSTAR has treated throughout the world,” noted GIOSTAR CEO and Co-Founder Deven Patel. “It’s only because of their trust in our capabilities that we’ve been able to grow our infrastructure.”
GIOSTAR Cancun Riviera offers several key benefits, including:
Great vacation destination: Cancun has long been regarded as one of the world’s most attractive vacation destinations, with beautiful beaches, vibrant nightlife, and ample shopping opportunities.
Easy access: the GIOSTAR facility is located near Mexico’s second largest airport (Cancun International Airport), making it accessible via direct flights from numerous cities throughout the world.
Therapies backed by decades of research: GIOSTAR Cancun Riviera’s highly skilled professionals are trained extensively in the lab techniques and protocols developed by GIOSTAR Chairman and Co-Founder, Dr. Anand Srivastava.
Due to these advantages, Mr. Patel remarked that “this center helps GIOSTAR to continue executing on our mission to make the most advanced, elite, and expensive science available to the masses.”
As with the GIOSTAR center in Los Algodones, Mexico, GIOSTAR Cancun Riviera is integrated with other facilities such as the Sani Dental Group dental clinic. This provides patients the opportunity to receive comprehensive health care while taking advantage of the amenities offered in the surrounding Playa del Carmen area.
Additionally, the colors of the walls and furniture, the wood used in the fixtures, and other aesthetic elements of the center are closely aligned with those of the Mayan Riviera. “We wanted the center to look as authentic (yet modern) as possible,” noted GIOSTAR Mexico Chief Operating Officer Alejandro Gutiérrez. “The Cancun Riviera facility reflects Dr. Srivastava’s belief that stem cell therapy patients will maximize their success rate when they’re in a relaxed state of mind.”
Upcoming plans for 2020 include an “official inauguration event” in February, along with tentative plans to open an additional center in Mexico.
GIOSTAR is the pioneer and established leader in the field of regenerative medicine. Under Dr. Anand Srivastava’s leadership, the San Diego-based Institute has a tradition of groundbreaking research in the field of stem cell science spanning more than two decades.
GIOSTAR Chairman and Co-founder Dr. Anand Srivastava and Vice Chancellor, Dr. Mohammed Basheer of Calicut University, Kerala Signed an Agreement to Develop Advanced Stem Cell Center under the direction of GIOSTAR