Health Talk on Stem Cell Sciences in Asian Medical Institute Kyrgyzstan on 26th May 2022 By Dr. Anand Srivastava Chairman GIOSTAR USA
Health Talk on Stem cell sciences in Asian Medical Institute Kyrgyzstan on 26th May 2022 By Dr. Anand Srivastava Chairman GIOSTAR USA
Dr. Anand Srivastava has been appointed as a Chairman of the International Accreditation for Educational Institutions. He is responsible for evaluating the quality of education in the Medical School and recommending the renewal of the license.
IMPROVING THE QUALITY OF HUMAN LIFE WITH HELP OF STEM CELL SCIENCE GIOSTAR
GIOSTAR Awarded As 50 Most Influential Companies Of The Year 2021
The concept of regenerative medicine using the body’s stem cells and growth factors to repair tissues may become a reality as new basic science works and initial clinical experiences have “teamed up” to develop alternative therapeutic strategies to treat various previously untreatable diseases. Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries, and other health-related conditions. Necessary clinical trials involving stem cells are underway for many different conditions, and researchers continue to explore new avenues using stem cells in medicine.
Some companies worldwide have not limited the use of stem cell therapy to just research and have been using ethically sourced stem cells to treat many health problems, from diseases to cancer. One of the global leaders in stem cell therapy and research is the Global Institute of Stem Cell Therapy and Research (GIOSTAR). GIOSTAR was formed with the vision to provide stem cell-based therapy to aid those suffering from degenerative or genetic diseases around the world. GIOSTAR can treat several devastating immunological disorders and blood-related diseases.
Blood donation camp & Free Ortho OPD Camp organized by GIOSTAR Chandigarh Branch on 13th Nov 2021. Camp was opened by Chief Guest Kulwant Singh Ex Mayor Mohali City. & Guest of Honour Dr. Seemha Rai Chairperson Centre of Stem cell, Tissue engineering & Bio Medical Excellence Panjab University. Around 84 Blood Donors donate their Blood in this camp.
Leading India towards an Immune Future
In August 2020, a 53-year-old COVID patient who was in a comatose state, struggling to hold on to life, was infused with Mesenchymal stem-cells taken from an umbilical cord. The results of this infusion were nothing less than enthralling as the patient recovered significantly in over three weeks.
This medical marvel was made possible by Global Institute of Stem Cell Therapy and Research (GIOSTAR), which is on a mission to administer the safest and most effective stem cell therapies and to deliver the highest quality care through its hospitals.
GIOSTAR was founded on the vision to provide stem cell-based therapy to people suffering from all kinds of degenerative or genetic diseases around the world. The company is evidently a leader in developing cutting edge stem cell-based technology, supported by leading scientists with pioneering publications in the area of stem cell biology. GIOSTAR was also one of the first company/research institute in the world which received USA-FDA approval in April 2020 to treat COVID-19 patients with stem cells.
The company’s primary focus is on discovering and developing a cure for human diseases through state-of-the-art and unique stem cell-based therapies and products. The company’s intellectual property, intellectual assets and technology have been developed over its team working on research projects funded to the tune of more than several hundred million dollars.
GIOSTAR is a coalition of esteemed and illustrious scientific minds in the field of genetic and stem cell science. The company’s team members have been involved in the development and utilization of stem cell based clinical protocols related to malignant and non-malignant diseases for the last 20 years.
The company’s leaders are associated with leading universities and research institutes of USA. GIOSTAR is affiliated with University of California San Diego Medical College (UCSD), University of California Irvine Medical College (UCI), Salk Research Institute, San Diego, Burnham Institute for Medical Research, San Diego, University of California Los Angeles Medical College (UCLA), USA, Harvard Medical School, Imperial College, London.
“Our team has developed several research collaborations and has an extensive research experience in the stem cell therapy which is documented by several publications in revered scientific journals,” says Dr Anand Srivastava, the Chairman and Co-founder of GIOSTAR.
Dr Srivastava’s profound success has its root in his unique background and expertise in stem cell biology, protein biochemistry, molecular biology, immunology, in utero transplantation of stem cell, tissue targeting, gene therapy and clinical research.
There are many scientists who can work in a narrowly defined field, but few have broad and multidisciplinary experience to carry out clinical research in a field as challenging as stem cell biology, cancer, and gene therapy. Dr Srivastava’s wide-spectrum expertise is rare in clinical research and perfectly crafted to fit ideally with the GIOSTAR’s projects for stem cell transplant, cancer, and gene therapy research. Dr Srivastava is also serving as stem cell director for the government of Gujarat, India and is in the process of establishing the stem cell program for Gujarat, Government of India.
The team at GIOSTAR is reaching heights of success also under the able leadership of Mr. Deven Patel, the CEO, President and Cofounder. Mr. Patel was honoured with USA Congressional Recognition for his efforts in spreading the advancement of stem cell science around the world. He was also bestowed with the Asian Heritage Award for his business leadership in the field of stem cell science.
GIOSTAR, under the leadership of Mr. Patel, is heading the development of stem cell transplant program for four different State Governments in India with total population of approx. 155 million. The company, in collaborations with Government of Gujarat, India, has founded the world’s largest state-of-the-art stem cell treatment hospital in India. GIOSTAR is also in process of developing additional facilities in China, Thailand, Colombia, Bahamas, Dubai, and Australia.
Talking about how GIOSTAR successfully found the solution to treat COVID-19 related health issues, Dr Srivastava explains, “COVID-19 infection leads to uncontrolled release of proinflammatory cytokines known as ‘cytokine storms’ that potentially lead to fatal damage of many organs of the body. MSCs have specific characteristics that, when infused in the bloodstream, neutralize proinflammatory cytokines (through ‘immunomodulation’), down-regulate the inflammatory gene actions and send messages to regenerate damaged lung and other tissues, which may help in managing COVID-19.” GIOSTAR is also gearing up to start its clinical trial for patients with aftereffects of COVID-19 on lungs and other organs.
We asked Dr Srivastava about his opinion on the necessity for businesses to align their offerings with newer technological developments, especially when it comes to changing industry trends and customer preferences, to which he replied, “Scientific research is an ever-evolving process. GIOSTAR being hard core research organization allows it to be at the forefront of new innovations and possible cure for several incurable disease. This same mindset has made us one of the first research institutes in the world to get very early approval form USA-FDA to treat COVID-19 patients with stem cells.”
Mr. Patel on the other hand shared a few tokens of knowledge through the commercial perspective of regenerative medicine development, he says, “The pharma and scientific research businesses are very competitive, at very high level of science and at very high cost. Therefore, a simple advice to aspiring entrepreneurs is to first get their ducks in the row and get your finances figured out way in advance, otherwise it is very easy to bankrupt the company in this volatile economy.”
GIOSTAR’s plan to continue scaling its operation, keeping in mind the unpredictable future, can be viewed to be agile and ready to run. Pertaining to stable finances, the company’s pipeline of several technologies is very robust and in line with its projections. GIOSTAR is poised to be the largest stem cell research and therapy company on the earth. The company is already becoming a synonym for the stem cell treatment.
GIOSTAR Announces FDA Approval Under Compassionate Use for a COVID-19 with Stem Cells
GIOSTAR Received FDA Approval Under Expanded Access For Use of Stem Cells to Treat COVID-19 Patients
Under expanded access, also known as compassionate use, the U.S. Food and Drug Administration (FDA) has approved GIOSTAR the emergency use of stem cell therapy to treat acute inflammation of the lungs in hospitalized patients diagnosed with COVID-19. Expanded access allows patients to receive stem cell therapy on a case-by-case basis outside of a conventional clinical trial as deemed appropriate by the treating physician, the GIOSTAR medical director and the FDA. Each patient will be assessed to determine if stem cell therapy is appropriate and a separate Investigational New Drug (IND) application will be filed for the FDA’s approval every single time. Patients will be evaluated after the infusion of the stem cells and the outcome of the treatment will be submitted to the FDA regularly.
Treatment of COVID-19 patients with mesenchymal stem cells (MSCs) has been shown to be beneficial in a number of studies from USA, Israel, China and UAE[Admin1] . In the U.S., the FDA approved a clinical trial to study use of umbilical cord stem cells in the treatment of COVID-19 patients https://newsroom.baptisthealth.net/press-release/fda-approves-covid-19-trial-after-successful-emergency-use-of-umbilical-stem-cells-from-restem/
COVID-19 infection causes an acute flow of inflammatory cytokines like IL-6, GCSF, IP10, MCP-1, MIP1A, and TNF-α in the lungs, which cause and promote formation of microthrombi. These microthrombi can block normal flow of blood in any part of the body leading to pathogenesis in the afflicted organ. This could be a very probable reason as COVID-19 has been shown to affect any part of the body like brain, heart, kidneys, intestines and of course the lungs.
The MSCs, known for its immunomodulatory character and secret a lot of anti-inflammatory cytokines and suppress the pro-inflammatory cytokines. After infusion in COVID-19 patients, MSCs have been shown to have high expression of anti-inflammatory and trophic factor genes like HGF, LIF, NOA1, VEGF, EGF, BNDF and NGF to name a few. These anti-inflammatory cytokines may help alleviate the COVID-19 symptoms. Transplantation of ACE2-Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia Aging and disease (2020) 11: 216-228;Cytokine release syndrome in severe COVID-19 Science (2020) 368-473-474
Groundbreaking research provides a promising potential alternative to devastating pandemic
Global Institute of Stem Cell Therapy and Research (GIOSTAR), the worldwide leader in stem cell research, is pleased to announce that they have received an approval for COVID-19 clinical trial, led by their Medical Director Dr. Prabhat Soni. GIOSTAR will conduct the trials using stem cells to treat COVID-19 patients, under the approval of the United States Food and Drug Administration (FDA) “expanded access for compassionate use” program. The Institute is exploring a promising alternative approach to the devastating disorder, which leverages the anti-inflammatory properties of mesenchymal stem cells (MSCs). According to Dr. Soni, the investigation is based upon two decades of stem cell research by GIOSTAR Co-Founder, Chairman and Chief Scientific Officer Dr. Anand Srivastava.
The COVID-19 pandemic has resulted in unprecedented disruption, with more than 3 million cases and 200,000 deaths reported worldwide as of May 1, 2020 – a figure that is projected to grow exponentially in the weeks ahead. Caused by a pathogenic virus known as SARS-CoV-2, the infection induces a broad range of responses in humans: some patients are asymptomatic, others develop mild flu-like discomfort, and still others suffer from severe pneumonia. Physicians have resorted to numerous traditional and unconventional therapies to combat the effects of COVID-19. These therapies – which include antibiotics and plasma therapy – have proven largely ineffective in managing the spread of the pandemic.
A Novel Approach to Inflammation
Given these challenges, there has unsurprisingly been a surge in clinical trials for use of MSC’s to combat COVID-19. Cedars-Sinai Medical Center recently cited studies that “support the notion that cell therapy can attenuate inflammation, which may be attractive in COVID-19.” One study by an international coalition of researchers from China, United States, India, France, and other countries appeared in Aging and Disease, showing full recovery of seven COVID-19 patients 2 weeks after receiving intravenous (IV) administration of allogeneic (sourced externally from donors) MSCs.
COVID-19 is induced by a release of signaling molecules known as cytokines – small protein molecules released by immune cells to orchestrate the “attack-and-destroy” mode of the host’s immune system response to pathogens. Cytokines are either proinflammatory (“bad”) or anti-inflammatory (“good”), meaning that they either increase or decrease levels of inflammation in the body. In the case of COVID-19, an uncontrolled immune response leads to a “cytokine storm,” dramatically raising levels of IL-6, IL-8, and TNF-alpha and other proinflammatory proteins. The immune system then goes into “overdrive” mode, thereby causing potentially fatal damage to the patient’s own tissues and organs.
Drs. Srivastava and Soni sought to leverage and apply extensive research demonstrating the effectiveness of MSCs in combating the respiratory symptoms and cytokine storms associated with COVID-19. “The cells have specific characteristics that, when infused in the bloodstream,” Dr. Srivastava explained in an educational video, “neutralize the proinflammatory cytokines, down-regulate the inflammatory gene actions (through ‘immunomodulation’), and send messages to regenerate damaged lung tissues.”
Seeing great potential in this therapeutic approach, the FDA approved MSC-based treatment for use in the most severe cases of COVID-19, under their “expanded access for compassionate use” program. The first patients will be treated in New York City. The city has been among the most severely impacted regions of the country, with more than 170,000 confirmed cases of COVID-19 and 13,000 deaths as of May 1, 2020.
“GIOSTAR appreciates the FDA for their timely action in approving the protocol,” noted Dr. Soni. “We’re looking forward to sharing the findings from our studies with the world, which may help save many lives in the future.”
GIOSTAR is the pioneer and established leader in the field of stem cell research. Under the leadership of Co-Founders Dr. Anand Srivastava and Deven Patel, the San Diego-based Institute has a tradition of groundbreaking research in stem cell science spanning more than two decades.
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