Global Institute Of Stem Cell Therapy And Research

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Cardiovascular diseases

What Sets Us Apart

Headquartered in U.S.A.
Founder is leading stem cell scientist credited with setting up the stem cell research programs at top research institutions in U.S.A. including Salk Research Institute, Sanford-Burnham Institute, UCI, UCSD.
Medical Advisory Board comprising of luminaries from Harvard, University of California, San Diego (UCSD), University of California Irvine (UCI), Imperial Collage, London
Endorsed by Honorable Prime Minister of India.
State of the art and only private hospital in India inaugrated by Prime Minister.

What is Cardiovascular Disease?


Cardiovascular diseases, comes under range of diseases affecting the heart. It is an umbrella term for many difficulties such as coronary artery disease, heart rhythm problem and heart defects. It can also be referred as common term involving narrowed or blocked blood vessels leading to heart attack, chest pain or stroke.

How prevalent is Cardiovascular Disease?

Cardiovascular disease is the global cause of death, accounting for 23.6 million deaths by the end of 2030. The study has concluded that in US itself, almost one individual is affected by the heart problems once after every 43 seconds. It is known to be more prevalent in women than in men and is supposed to take more lives than all forms of the cancer combined.

Stem Cell Treatment for Heart Diseases

Factors responsible for Heart Disorders

The American heart association have suggested that people should track 7 key factors and behaviour that can increase the risk associated with the disease. They have been known as life simple 7. They can be:-

  • Smoking: – Worldwide tobacco smoking including passive smoking can be considered as the major risk factor associated with the cardiovascular diseases. This has contributed to almost 6.2 million deaths per year. 16% of the students, 20% of the men and 16% of the women are found to be controlled over by smoking.
  • Physical Activity: – About 1 in every three adults, almost 31%; agreed that they participate in no leisure time physical activity. Among students only about 27% follow the recommendation of 60 minutes of exercise every day.
  • Healthy Diet: – Less than 1 percent of the adult come in the category of people opting for the ideal healthy diet. Of the 5 most important requirements of healthy diet, reducing sodium and increasing whole grain portion are the biggest challenges. The consumption of calories has increased drastically from 1971 to 2004, it is observed that the average woman consumes about 1900 calories a day and that of a man consumes about 2700 calories a day.
  • Obesity: – About 71% of the adults are reported to be overweight or obese. Obesity can reduce the cardiac efficiency to a great extent.
  • Cholesterol: – More than 50% of the people have reported to be having high cholesterol content, more than 200 mg/dl. The cholesterol deposition can block the artery or blood vessels causing a problem of ischemic heart attack.
  • High Blood Pressure: – More pressure on the walls of the arteries can make them vulnerable, decreasing the cardiac output. High blood pressure is reported in almost 80% of the people. The reported hypertension is reported to increase in about 8-10% of the people every year.
  • Diabetes: – Diabetes is the condition wherein blood sugar level is increased due to faulty metabolism of the glucose. Body converts the increased blood sugar into the fat and stores for the future use. This fat can be deposited in the arteries blocking their efficiency.

Apart from these reported simply 7, other factors family history; ethnicity sex and age are other factors responsible for CVHD.

Symptoms Associated with the CVHD

CVHD is caused by narrowed, blocked or hardened blood vessels due to which the flow of blood to important organs of the body is obstructed. However, CVHD symptoms can be different for men and women like men are more likely to have chest pain on the contrary women can experience shortness of breath, nausea and extreme fatigue. The truth is that people might not be able to diagnose with CVHD until and unless they get heart attack, pain, angina, etc. Thus it is very important to keep a check on the symptoms of the CVHD and if any of these symptoms are observed person should immediately consult doctor.  The common symptoms can include

  • Chest pain or angina.
  • Shortness of breath.
  • Pain, numbness, weakness or coldness in legs or arms if the blood vessels on those parts of the body are narrowed.
  • Pain in the neck, throat, jaw and the upper abdomen or back.

Apart from the above noted symptoms, abnormal heart beats are also mainly reported to be the common reasons for heart diseases. The symptoms may include

  • Fluttering in chest
  • Racing Heartbeats
  • Slow Heartbeats
  • Chest pain or discomfort
  • Shortness of breath
  • Dizziness
  • Fainting or near fainting

Symptoms associated with the weak heart muscles or dilated cardiomyopathy can be

  • Breathlessness with exertion or even at rest
  • Swelling in the legs, ankles and feet
  • Fatigue
  • Fluttering, irregular heart beats
  • Dizziness, light-headedness and fainting

Symptoms associated with the heart infection can be

  • Fever
  • Shortness of breath
  • Fatigue, weakness
  • Swelling in legs or abdomen
  • Changes in your heart rhythm
  • Skin rashes or unusual rashes
  • Dry or persistent cough

Prognosis associated with the Heart Disorders

The diagnosis of heart disease has improved considerably with better understanding of the typical and atypical symptoms experienced by many adults. It has been as well found that the prognosis of the heart disease is better when both diagnosis as well as treatment has started in the initial phase. The research has suggested that it takes almost 15 years from the beginning of the plaque formation till the time the artery is completely constricted. Thus increasing the public awareness about the early access to emergency services when strong pain is experienced can decrease the death rate to the considerable extent.

The American heart foundation has developed guidelines to minimize the risk associated with the heart diseases.  A new attention has been emphasized in weight reduction, diet, exercise and the use of cholesterol lowering drugs.

What goes wrong in the CVHD?                        

Heart diseases are strongly classified in three broad categories as follows:-

  • Coronary Heart Diseases: – This occurs when the flow of oxygen rich blood is reduced to a great extent or even blocked by a build up of fatty material in the coronary arteries. These coronary arteries are the two major blood vessels that supply blood to the heart. As these arteries are narrowed due to plaque formation there can be a considerable chest pain called as angina whereas if these arteries are completely blocked then it can cause heart attack.
  • Peripheral Artery Diseases: – Peripheral artery diseases can also be known as peripheral vascular diseases, occur when the blood to the limbs is obstructed; usually legs. The most common symptoms associated with this difficulty are dull pain in legs, heavy sensation in the leg muscles,
  • Aortic Diseases: – The aorta, being the largest blood vessel in the body carrying blood from the heart to other vital organs, is blocked due to plaque formation. Due to this blockage the artery gets swollen and weak; bulging outward.

How Stem Cells treatment can help!

Stem cells are the mother cells that are responsible for developing an entire human body from a tiny two celled embryo; due to their unlimited divisions and strong power to differentiate into all the cells of different lineage. This power of stem cells has been harnessed by the technology to isolate them outside the human body, concentrate in the clean environment and implant back.

Thus, stem cells treatment involves administration of concentrated cells in the targeted area, wherein they can colonize in the damaged area, adapt the properties of resident stem cells and initiate some of the lost functions that have been compromised by the disease or injury.

The compiled data from different research has evidently suggested the differentiation of stem cells into cardiomyogenic lineage. The stem cells are known to express angiogenic properties increasing the network of blood vessels, maximizing the flow of blood and improving the heart efficiency. The mesenchymal stem cells isolated from both allogenic as well as autologous sources are known to be differentiating into myogenic lineage, improving the cardiac pumping.

Treatment of Heart Diseases at GIOSTAR

We have mastered the technology for isolating maximum number of viable stem cells from either the autologous sources of your own body or allogeneically with the matched donor to treat various children with ASD. We are the licensed, private organization with the excellent, well equipped state of the art facility to isolate process and enrich the viable number of stem cells, which can be re infused back into the patient’s body. Generally, these cells are administered through any one of the below mentioned methods depending upon our expert’s advice:

  • Local Administration:-Through this mode, cell are infused directly at the targeted site of injury. Thus in case of heart diseases, stem cells are infused through intra myocardial or intra coronary route, directly into the heart.
  • Intravenous Administration:- Through this mode, cells are infused through the veins along with the mannitol to expand blood volumes in the central nervous system, to ensure that the maximum number of cells are reaching to the targeted area.

Once infused back in the body, these cells can be repopulated at the damaged parts of the cardiovascular system, through their strong paracrine effects and differentiate into lost or damaged heart cells, muscles and create new blood vessels to improve the supply of blood or help in production of supporting cells to improve the functioning of the cardiovascular system.

Thus with our standardized, broad based and holistic approach, it is now possible to obtain noticeable improvements in the patients with the heart diseases, in the symptoms as well as their functional abilities. 

WHAT SETS US APART

  • US Head quartered.
  • Founder is leading stem cell scientist credited with setting up the stem cell research labs at top research     institutions in US including Salk Research Institute, Sanford-Burnham Institute, UCI, UCSD.
  • Medical Advisory Board comprising of luminaries from Harvard, * University of California, San Diego (UCSD), University of California Irvine (UCI), Imperial Collage, London.
  • Endorsed by Honourable Prime Minister of India.
  • State of the art and only private hospital in India inaugurated by Prime Minister.
  • World’s largest stem cell hospital funded by government.

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