Global Institute Of Stem Cell Therapy And Research

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Stem Cell News

Stem Cell Revolution Trudges Forward

We are still in the early stages [of stem cell treatment]. In 2014, Dr. Masayo Takahashi and her colleagues at the Riken Center for Developmental Biology had great success using iPS cells to treat macular degeneration.

In some ways, yes, [the promise of stem cells] is overstated. For example, target diseases for cell therapy are limited. There are about 10: Parkinson’s, retinal and corneal diseases, heart and liver failure, diabetes and only a few more — spinal cord injury, joint disorders and some blood disorders…The number of human diseases is enormous.

Stem Cell Revolution Trudges Forward

I think the science has moved too far ahead of talk of ethical issues. When we succeeded in making iPS cells, we thought, wow, we can now overcome ethical issues of using embryos to make stem cell lines.

But soon after, we realized we are making new ethical issues. We can make a human kidney or human pancreas in pigs if human iPS cells are injected into the embryo. But how much can we do those things?

It is very controversial. These treatments may help thousands of people. So getting an ethical consensus is extremely important.

Source : https://goo.gl/1tIykZ

5th European Biosimilars Congress
June 27-29, 2016 Valencia, Spain
“The European perspective of Biologics and Biosimilars”

Meet World leading Biosimilar Industry Leaders from 50+ different Countries
I hope this message finds you well. I’m honored to request you to speak at 5th European Biosimilars Congress happening from June 27-29, 2016 Valencia, Spain and would be so excited if you would join us.
Euro Biosimilars 2016 is a three day event with an audience from leading industries of Biosimilars and follow-on-Biologics sector, contract research organizations, research institutes, patent attorneys, domestic and international regulatory agencies and executive directors of leading biopharmaceutical companies and experts.
Our goal is to bring together bright minds to give talks that are idea-focused, and on a wide range of subjects, to foster learning, inspiration and wonder – and provoke conversations that matter.
UNIQUE FEATURES OF EURO BIOSIMILARS 2016
•Our robust on-line publicity attracts 20000+ users and 60000+ views to our Library of Abstracts which brings worldwide exposure to the researchers and speakers participate in our conferences.
•The Career Guidance Workshops to the Graduates, Doctorates and Post-Doctoral Fellows
•Accepted Abstracts will be published in PubMed, MEDLINE, ProQuest, SCOPUS, SOCOLAR, EBSCO, CAS, Hinari, Index Copernicus, Google Scholar, SCIRUS, DOAJ indexed journals.
•Each abstract will be labeled with a Digital Object Identification Number (DOI) provided by Cross Ref
•Speaker and Abstract pages created in Google on your name would get worldwide acknowledgment to your research profile
CONFERENCE TOPICS
• Current Challenges of Biologics
• Emerging Biosimilars in Therapeutics
• Legal Issues
• Regulatory Approach for Biosimilars
• Biosimilars Innovator Pharmaceutical Products
• Plant Produced Biosimilars
• Bioequivalence Assessment
• Biosimilar Analytical Strategies
• Intellectual Property Rights
• Globalization of Biosimilars
• BCS & IVIVC Based Biowaivers
• Biosimilar Market Analysis
• Biosimilars Pharmacovigilance
• Clinical Studies on Biosimilars
• Entrepreneurs Investment Meet
Benefits:
•Keynote sessions by world’s most eminent researchers and Networking with Experts in the field of Pharma
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•e-Poster for $99
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•Top Industries Representation
For more details visit our website http://biosimilars-biologics.pharmaceuticalconferences.com/europe/
The Euro Biosimilars 2016 Committee is pleased to announce that they are currently accepting proposals for Symposia and Workshops on the above given topics. All proposals must be submitted to: eurobiosimilars@conferenceseries.com
We believe your voice would be a critical addition to the Euro Biosimilars 2016 stage. Thank you for reading, and we very much look forward to hearing from you.
Best Regards
Badoni Victor
Program Manager- Euro Biosimilars 2016
Email: biosimilars@conferenceseries.com
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Current Pharmaceutical Design

Dr. A. S. Srivastava                                                                                                                                                                                                                                                                               

Stem Cell Core Labratory
Salk Institute for Biological Studies La Jolla
CA 92037
United States

Dear Dr. Srivastava,

On behalf of the editorial board of “Current Pharmaceutical Design”, I would like to propose your name to be considered as an Executive Guest Editor for a thematic issue of the journal in a hot topic area.

“Current Pharmaceutical Design” is a leading international journal, which publishes frontier reviews in important fields of drug discovery. The journal is published by Bentham Science Publishers and has been widely acclaimed because of its excellent standards and the high quality of publications. It is abstracted/indexed in a number of major abstracting/indexing agencies, Impact Factor: 6.452 (2014 SCI Journal Citation Reports). Each issue is published under a Guest Editor who is an authority in the field and who is responsible for soliciting top class articles covering various important aspects of the field from leading authorities.

Bentham Science Publishers is currently publishing 42 issues of the journal annually. These “theme issues” contain articles in important fields of current research activity written by eminent experts in the field. The Guest Editor is responsible for soliciting top class articles covering various important aspects of the selected topic from leading authorities in the field. In view of current demand for the journal, the publishers are soliciting additional topic themes relevant to pharmaceutical design. Please visit the website of Current Pharmaceutical Design for more information.

If you are interested in being considered for the post of Executive Guest Editor, then please send us the following:

1. Title of your topic or theme.
2. List of authors (along with their affiliation) and the titles of the articles they are contributing.
3. Brief introduction of the issue.
4. A description stating how the subject will contribute to the field.
5. Your complete CV and detailed list of publications.

The aim of the journal is to provide readers with comprehensive accounts of recent developments in the frontier areas of the field. The articles should take the form of full-length manuscripts of recent developments in important areas related to pharmaceutical design within a therapeutic field. They could include accounts of the author’s research work combined with a review of the recent literature so that the readers will not only have the opportunity of benefiting from the author’s contribution, but will also gain access to a broader perspective of the field.

We will need to have about 250-300 printed pages in the journal issue from about 10-15 authors who are leading experts in the field (for manuscript preparation details please visit Author Guidelines Please note that no research articles will be accepted as a part of the thematic issue.

As the Executive Guest Editor, you will be required to contribute a one-page foreword highlighting the importance of the chosen topic and of the articles contained in the issue. You may also contribute an article to the issue yourself. You will be entitled to free online subscription to the whole volume of the journal for the year in which your issue has appeared. Appointment as the Executive Guest Editor is renewable by mutual agreement.

I would be grateful if you could please send your reply to me at thematicissue@benthamscience.org. as soon as possible along with the choice of the proposed theme/ topic area of your interest.

I shall be looking forward to receiving your positive reply.

Yours truly,

Prof. William A. Banks
Editor-in-Chief Current Pharmaceutical Design
Email: thematicissue@benthamscience.org.

                                                                                                                                                                               

Researchers found that after testing five SCID-X1 patients who received both gene therapy and low-dose chemotherapy, four of the patients showed improvements in immune function. Scientists from the National Institute of Allergy and Infectious Diseases (NIAID) have come up with a new gene therapy that can restore immunity…

The standard treatment would include a transplant of stem cells, which can be obtained from the direct family members. Only one of them unfortunately perished, due to a pre-existing condition that damaged their lungs before the new therapy could be applied. Currently, patients suffering from SCID-X1 are treated with stem cell transplants.

The National Institute of Allergy and Infectious Diseases reports a procedure including the extraction, genetic correction and reinsertion of a patient’s bone marrow can help their immune systems improve over time.

SCID-X1 is generally triggered by mutations in the IL2RG gene that averts infection-fighting immune cells from developing and working normally, leaving inflicted children highly vulnerable to life-threatening infections. One of the lifesaving treatments for very young children with SCID-X1 is transplantation of stem cells, ideally from a sibling donor who is genetically matched.

In the latest study, scientists examined the safety and effectiveness of gene therapy pooled with low-dose chemotherapy in five SCID-X1 patients.

Using a lentiviral vector, the scientists included a healthy IL2RG gene in the stem cells. The patients were then given low-dose chemotherapy to eliminate the defective blood cells. One patient received treatment three years ago with continued improvements. Another patient is doing well and continues to show improvement even after three years of the gene therapy. Three more patients aged 7 to 24 are improving, though it has only been three to six months since the treatment was performed. All surviving patients are continually being monitored.

Severe Combined Immunodeficiency is a rare immunodeficiency that leads to frequent serious infections. They manipulated the virus gene to deliver the right gene to the cell. By collecting an individual s stem cells and modifying them with a lentivirus, the gene-corrected cells can be returned into the blood to help produce normal healthy immune cells. Accessible treatments for this once-deadly disorder have centered around bone marrow transplants, yet encouraging results have been reported by an on-going clinical trial for an emerging gene therapy – Lentiviral gene transfer.

To determine the safety and effectiveness of lentiviral gene transfer as a treatment for children and adolescents with X-linked severe combined immunodeficiency.

Resource : http://goo.gl/nUrAFf

Regenerative medicine products are built via a combination of three elements: living cells, a matrix to support the living cells (i.e. a scaffold), and cell communicators (or signaling systems) to stimulate the cells, and their surrounding environment to grow and develop into new tissue.

These are special cells in the body that can turn into other types of cells. During the healing process, regenerative cells are called to the area of the body that needs repair. Factors in the area influence the regenerative cells to become repair cells.

Interestingly, the same regenerative cells that repair bone can also repair muscle, tendon, ligament, or cartilage. Of all of the types of cells, regenerative cells have the greatest potential to promote healing.

Regenerative cells are undifferentiated cells found in bone marrow that have the capacity to become bone, muscle, cartilage, ligament and tendon cells. Upon arrival to the injured tissue, regenerative cells take on the characteristics of that host tissue.

Stem Cell

This naturally occurring process is the body’s way of initiating the healing cascade. Because of the dramatic healing capabilities of regenerative cells, BioCellular Therapies has developed concise research and methods that will deliver an increased number of these cells, millions versus thousands, to injured tissue, thereby enhancing the healing process.

Isolating Adult Stem Cells

Using the body’s natural T- Cells for the tissue regenerative property which is highly concentrated in bone marrow. Isolating adult stem cells from a variety of tissues in addition to the blood allows for the ability to create a systematic approach, and specifically crafted treatment plan created specific to each patient.

It is understood that no two people are the same. Hence why we take the time to research and find out every detail of each patient. With our state of the art technology, and research we strive to create the best treatment plan. Upon countless hours of research our doctors do an in depth patient history, and develop the best plan possible for you.

Understanding Adult Stem Cells

ASC stands for adult stem cell. The adult stem cell can renew itself and can differentiate to yield some or all of the major specialized cell types of the tissue or organ. The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found. This is only found in adults.

Where Are ASCS?

Adult stem cells have been found in the brain, bone marrow, blood vessels, skeletal muscle, and other organs and tissues. They are in specific areas of each tissue, where they may remain dormant for years, dividing and creating new cells only when they are activated by tissue injury, disease or anything else that makes the body need more cells.

How Do We Get ASCS

Adult stem cells can be isolated from the body in different ways, depending on the tissue. Mesenchymal stem cells, which can make bone, cartilage, fat, fibrous connective tissue, and cells that support the formation of blood can also be isolated from bone marrow. Which is considered to be he most nutrient in the body of ASCs.

Focus Is On Cures

Regenerative medicine includes tissue engineering but also incorporates research on self-healing – where the body uses its own systems, sometimes with help foreign biological material to recreate cells and rebuild tissues and organs. The focus is on cures instead of treatments for complex, often chronic, diseases.

Source : http://goo.gl/by4YRS

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