Global Institute Of Stem Cell Therapy And Research

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Chronic Pain

What Sets Us Apart

Headquartered in U.S.A.
Founder is leading stem cell scientist credited with setting up the stem cell research programs at top research institutions in U.S.A. including Salk Research Institute, Sanford-Burnham Institute, UCI, UCSD.
Medical Advisory Board comprising of luminaries from Harvard, University of California, San Diego (UCSD), University of California Irvine (UCI), Imperial Collage, London
Endorsed by Honorable Prime Minister of India.
State of the art and only private hospital in India inaugrated by Prime Minister.

What is Chronic Pain Syndrome ?

 

Chronic pain syndrome is a common problem, affecting almost 40-50% of total world population. Pain is the sensation that is been triggered by the central nervous system as an alarm of a possible injury. However, in case of chronic pain, these signals are kept on firing by the nervous system, which can be continued for weeks, months and years. This type of pain can as well be called as neuropathic pain due to the pathological changes in neurons of the peripheral and central nervous system.

There need not be any past injury or evidences of any, body damage for the initialization of a chronic pain syndrome. The chronic pain can be defined as the pain that has lasted for more than 12 weeks and not responding to any treatments. Thus the chronic pain is considered to be more challenging than other disabilities as there are no objective evidences or findings, supporting the chronic pain and there are as such no medical tests available so far, which can measure its levels.

Chronic Pain Treatment in India

How prevalent is Chronic Pain Syndrome?

The chronic pain can be accounted for the most universal form of the human stress. The chronic pain syndrome being very common; its prevention, assessment and treatment are the principal challenges for healthcare providers. The prevalence rates of chronic pain syndrome may vary, but it is so far clear that almost more than 50% people only in the US are suffering from one or the other types of persistent pain. In a more detailed study, more than 45% of the people are suffering from musculoskeletal pain such as back pain, neck pain, knee pain, etc. Most recent data has confirmed that more than 13% of the people worldwide are suffering from the pain daily.

Factors responsible for Chronic Pain Syndrome

Chronic pain is the pain that last for more than normal healing period i.e. 1-2 weeks. In general, it is very difficult to evaluate the severity of pain because majority of the pain is classified as imaginary and only the patient can experience it. Furthermore, it has been observed to be disturbing sleep and hence degrades ones health and functional capacity. This can in turn be responsible for financial burden on the individual.

Some of the factors, which can be responsible for pain, are injury, disease, viral or bacterial infection, accidents, surgery, etc.

Symptoms Associated with the Chronic Pain Syndrome

The symptoms of the chronic pain may include

  • Mild to severe disturbing sensation such as shooting, burning, aching.
  • Feeling of discomfort, soreness, tightness or stiffness.

Apart from the sensation, other problems that are as well associated with the pain can include

  • Fatigue
  • Sleeplessness
  • Withdrawal from activity and increased desire to sleep.
  • More sensitivity to infection due to weak immunity
  • Frequent moon swings
  • Functional disability

Some of the other obvious causes, which are directly proportional to the severity and duration of the pain, are as follows:

  • Alcoholism
  • Limb or leg amputation
  • Diabetes
  • Facial nerve problems
  • Multiple Sclerosis
  • Spine Surgery

What goes wrong in the Chronic Pain Syndrome?

Chronic pain is a challenging condition wherein the pain remains active in the nervous system beyond the period of healing. The chronic pain need not be always an after effect of any injury or infection. This can take a toll on person’s physical, emotional and financial well being.

For instance, the most commonly, a chronic pain may originate from headaches, joint pain, back ache, etc. Other kinds of chronic pain may be originated from sports injury or generalized muscle or nerve pain can also be accounted into chronic conditions.

It is evidently observed that the above mentioned pathological changes can damage or weaken the neuron in the central nervous system. Due to this damage, the normal pain signalling process can be disturbed to the great level. This in turn can cause hyper sensitization or spontaneous neuronal activity of the nervous system and hence nerve within that system cannot work to transmit sensation to the brain. This leads to the sense of numbness due to which an individual may experience pain in the affected region.

How Stem Cells treatment can help!

Stem cells are the master cells that are responsible for developing an entire human body from a tiny two celled embryo; due to their unlimited divisions and strong power to differentiate into all the cells of different lineage. This power of stem cells has been harnessed by the technology to isolate them outside the human body, concentrate in the clean environment and implant back.

Thus, stem cells treatment involves administration of concentrated cells in the targeted area to form colonies; a peculiar characteristic of stem cells, adapt the properties of resident stem cells and initiate some of the lost functions that have been compromised by the disease or injury.

After years of research, it has been believed that it is better to alter the microenvironment with the application of stem cells instead of suppressing the immune system. Mesenchymal stem cells are known to have angiogenic, transdifferentiation and homing properties, which are useful for forming new blood vessels, differentiating into required targeted cells and creation of microenvironment for the faster secretion of immune cells.

These unique properties of stem cells may be exploited to differentiate them into neuronal origin to compromise with the nerve damage in a chronic neuropathic pain.

Treatment of Chronic Pain Syndrome at GIOSTAR

We have mastered the technology for isolating maximum number of viable stem cells from either the autologous sources of your own body or allogeneically with the matched donor to treat various patients with chronic pain. We are the licensed, private organization with the excellent, well-equipped state of the art facility to isolate process and enrich the viable number of stem cells, which can be re-infused back into the patient’s body. Generally, these cells are administered through any one of the below-mentioned methods depending upon our expert’s advice:

  • Local Administration:-Through this mode, cell are infused directly at the targeted site of injury.
  • Intravenous Administration:- Through this mode, cells are infused through the veins along with the mannitol to expand blood volumes in the central nervous system, to ensure that the maximum number of cells are reaching to the targeted area.

Once infused back in the body, these cells may be repopulated at the damaged parts of the organ, through their strong paracrine effects and differentiate into lost or damaged cells to restore back the function. These stem cells are known to create a suitable microenvironment to accelerate the secretion of growth factors, promote the differentiation of targeted cells e.g. in case of chronic pain syndrome, brain cells of central nervous system are generally targeted. This will help to restore back the lost function.

Thus with our standardized, broad-based and holistic approach, it is now possible to obtain noticeable improvements in the patients with the chronic pain syndrome, in the symptoms as well as their functional abilities.

WHAT SETS US APART

  • US Head quartered.
  • Founder is leading stem cell scientist credited with setting up the stem cell research labs at top research     institutions in US including Salk Research Institute, Sanford-Burnham Institute, UCI, UCSD.
  • Medical Advisory Board comprising of luminaries from Harvard, * University of California, San Diego (UCSD), University of California Irvine (UCI), Imperial Collage, London.
  • Endorsed by Honourable Prime Minister of India.
  • State of the art and only private hospital in India inaugurated by Prime Minister.
  • World’s largest stem cell hospital funded by government.

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